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Sitravatinib Chemical Structure

Sitravatinib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP29099CAS No. :1123837-84-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1123837-84-2 Cat. No. BCP29099
Name Sitravatinib
Synonyms MGCD516; MGCD-516; MGCD 516; MG516; MG 516; MG-516;
SMILES COCCNCC1=CN=C(C=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
Chemical Name
Formula C33H29F2N5O4S M. Wt 629.68
Purity 98% Storage Store at 4-8°C
Description Sitravatinib, also known as MGCD516 or MG516, is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth. MGCD516 treatment resulted in significant blockade of phosphorylation of potential driver RTKs and induced potent anti-proliferative effects in vitro. MGCD516 treatment of tumor xenografts in vivo resulted in significant suppression of tumor growth.
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