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SU14813 Chemical Structure

SU14813

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP27700CAS No. ：627908-92-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 627908-92-3 Cat. No. BCP27700
Name SU14813
Synonyms SU-14813;SU 14813; SU014813; SU-014813; SU 014813;
SMILES
Chemical Name
Formula C23H27FN4O4 M. Wt 442.48
Purity 98% Storage Store at 4-8°C
Description SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), KIT, and fms-like tyrosine kinase 3 (FLT-3) (1). SU14813 was developed as a next-generation TKI agent following sunitinib (SU11248) designed to demonstrate optimized pharmacokinetic (PK) and tolerability profiles. SU14813 demonstrated broad and potent antitumor activity equivalent to that of sunitinib, which resulted in tumor regression, growth arrest, growth delay, and prolonged survival in established xenograft cancer models in mice.
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