CAY10594 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP30751CAS No. ：1130067-34-3Purity：98%

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CAS No.	1130067-34-3	Cat. No.	BCP30751
Name	CAY10594
Synonyms	CAY 10594;CAY-10594;
SMILES	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5C=C4
Chemical Name
Formula	C26H28N4O2	M. Wt	428.53
Purity	98%	Storage	Store at 4-8°C
Description	CAY10594 is a potent PLD2 inhibitor, both in vitro (IC50 = 140 nM) and in cells (IC50 = 110 nM). It is also effective as a PLD1 inhibitor at higher concentrations (IC50 = 5.1 μM in vitro, 1.0 μM in cells). CAY10594 strongly inhibits the invasive migration of breast cancer cells in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion. Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are regulated differently and apparently subserve distinct roles.