AZD4877

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP07430CAS No. ：1176760-49-8Purity：98%

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CAS No.	1176760-49-8	Cat. No.	BCP07430
Name	AZD4877
Synonyms	AZD-4877;AZD 4877;
SMILES
Chemical Name
Formula	C28H33N5O2S	M. Wt	503.66
Purity	98%	Storage	Store at 4-8°C
Description	AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Eg5 is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.