PIM447
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1210608-43-7 | Cat. No. | BCP19936 |
| Name | PIM447 | ||
| Synonyms | LGH-447;LGH447;LGH 447;PIM-447;PIM 447; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H23F3N4O | M. Wt | 440.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | In vitro: PIM447 is cytotoxic for myeloma cells due to cell cycle disruption and induction of apoptosis mediated by a decrease in phospho-Bad (Ser112) and c-Myc levels and the inhibition of mTORC1 pathway. PIM447 also inhibits in vitro osteoclast formation and resorption, downregulates key molecules involved in these processes and partially disrupts the F-actin ring, while increasing osteoblast activity and mineralization. In vivo: PIM447 significantly reduces the tumor burden and preventes tumor-associated bone loss in a disseminated murine model of human myeloma. | ||
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