RO2959 Hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1219927-22-6 | Cat. No. | BCP37822 |
| Name | RO2959 Hydrochloride | ||
| Synonyms | RO2959 HCl;RO 2959 HCl;RO-2959 HCl;RO-2959 Hydrochloride; | ||
| SMILES | CC1=C(CN(CC1)C2=NC=C(S2)C)C3=CN=C(C=N3)NC(=O)C4=C(C=CC=C4F)F.Cl | ||
| Chemical Name | |||
| Formula | C21H20ClF2N5OS | M. Wt | 463.93 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways. | ||
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