Rosiglitazone
Data Sheet
For research use only. Not for human use.
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| CAS No. | 122320-73-4 | Cat. No. | BCP03047 |
| Name | Rosiglitazone | ||
| Synonyms | Avandia;BRL-49653;BRL 49653;BRL49653; HSDB 7555; HSDB-7555; HSDB7555; TDZ 01; TDZ-01; TDZ01; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H19N3O3S | M. Wt | 357.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Rosiglitazone (Avandia) has recently been identified as a high-affinity ligand for PPARγ, a nuclear hormone receptor that is abundantly expressed in adipocytes and plays a central role as a regulator of terminal adipocyte differentiation. Rosiglitazone (Avandia) acts primarily by increasing insulin sensitivity. Rosiglitazone (Avandia) improves glycemic control while reducing circulating insulin levels. Rosiglitazone (Avandia) is a member of the thiazolidinedione class of drugs. They reduce glucose, fatty acid, and insulin blood concentrations. They work by binding to the peroxisome proliferator-activated receptors (PPARs). Thiazolidinediones enter the cell, bind to the nuclear receptors, and affect the expression of DNA. Rosiglitazone (Avandia, BRL-49653) also appears to have an anti-inflammatory effect in addition to its effect on insulin resistance. | ||
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