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Alectinib Chemical Structure

Alectinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02589CAS No. ：1256580-46-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1256580-46-7 Cat. No. BCP02589
Related Products 1256589-74-8（Alectinib Hydrochloride）
Name Alectinib
Synonyms AF 802; AF-802; AF802; CH5424802; CH5424802; CH 5424802; RO5424802; RO 5424802; RO5424802;
SMILES
Chemical Name
Formula C30H34N4O2 M. Wt 482.62
Purity 98% Storage Store at 4-8°C
Description Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth.
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H-NMR LCMS
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