ASK1IN1

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP19368CAS No. ：1262041-49-5Purity：98%

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CAS No.	1262041-49-5	Cat. No.	BCP19368
Name	ASK1IN1
Synonyms	ASK1-IN-1;
SMILES
Chemical Name
Formula	C23H21N7O	M. Wt	411.46
Purity	98%	Storage	Store at 4-8°C
Description	InVivo: ASK1-IN-1dose-dependently decreases pulmonary arterial pressure and right ventricular (RV) hypertrophy in an in vivo model of pulmonary hypertension (PH). ASKl inhibition reduces hallmarks of pulmonary vascular disease including and not limited to reduce pulmonary vascular resistance (PVR), improve pulmonary pressure, decreased pulmonary vascular remodeling, improved vascular function, decrease maladaptive RV hypertrophy, and improve RV function. Inhibition of ASKl signaling may slow, prevent, and/or reverse pathological changes associated with PH. Plasma levels of B-type natriuretic peptide (BNP) are reduced by both doses of ASK1-IN-1: 0.1+0.05 for 0.1% and 0.1±0.1 ng/mL for 0.2%. Su/Hx rats treated with 0.1 % or 0.2% ASK1-IN-1 has a decreased number of completely muscularized arterioles (35.6% and 32.6%, respectively).