CCT241736

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP29563CAS No. ：1402709-93-6Purity：98%

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CAS No.	1402709-93-6	Cat. No.	BCP29563
Name	CCT241736
Synonyms	CCT 241736；CCT-241736;
SMILES	CC1=NN(C)C=C1C2=NC3=C(N4CCN(CC5=CC=C(Cl)C=C5)CC4)C(Cl)=CN=C3N2
Chemical Name
Formula	C22H23Cl2N7	M. Wt	456.37
Purity	98%	Storage	Store at 4-8°C
Description	CCT241736 is a novel, orally bioavailable, imidazo[4,5-b]pyridine derivative discovered at our Institute, highly selective for FLT3 and Aurora kinases with an S(10) selectivity score using KINOMEscan™ technology of 0.057 (fraction of 386 non-mutant kinases inhibited >90% when screened at 1 uM of CCT241736; San Diego, CA).In biochemical kinase studies, CCT241736 has IC50 values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 uM respectively. Furthermore, CCT241736 inhibits a wide range of FLT3 mutants, including FLT3-ITD, -D835Y, -D835H, -K663Q and –N841I. In cellular assays, CCT241736 inhibits viability of the human FLT3-ITD positive AML cell lines MOLM-13 and MV-4-11 with EC50 values of 0.1 and 0.27 uM respectively.