MAX-40279 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP46002CAS No. ：2070931-57-4Purity：98%

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CAS No.	2070931-57-4	Cat. No.	BCP46002
Related Products	2388506-44-1（MAX-40279 hemiadipate ） 2388506-43-0（MAX-40279 hemifumarate）
Name	MAX-40279
Synonyms	MAX 40279; MAX40279;
SMILES	CC1=C(C2=NC(=NC=C2S1)NC3=CN(N=C3)C4CCNCC4)C5=C(C=C(C=C5)F)OC
Chemical Name
Formula	C22H23FN6OS	M. Wt	438.52
Purity	98%	Storage	Store at 4-8°C
Description	FLT3/FGFR Dual Kinase Inhibitor MAX-40279 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon oral administration of FLT3/FGFR dual kinase inhibitor MAX-40279, this agent binds to and inhibits both FGFR and FLT3, including FLT3 mutant forms, which results in the inhibition of FGFR/FLT3-mediated signal transduction pathways. This inhibits proliferation in FGFR/FLT3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases, is upregulated in many tumor cell types. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. They both play key roles in cellular proliferation and survival.