Donafenib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP34023CAS No. ：1130115-44-4Purity：98%

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CAS No.	1130115-44-4	Cat. No.	BCP34023
Name	Donafenib
Synonyms	Sorafenib (D3); CM-4307; CM 4307; CM4307;Bay 43-9006 (D3);
SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
Chemical Name
Formula	C21H13D3ClF3N4O3	M. Wt	467.85
Purity	98%	Storage	Store at 4-8°C
Description	Donafenib is an orally available multikinase inhibitor that targets Raf kinase and various receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Upon oral administration, donafenib binds to and blocks the activity of Raf kinase, and inhibits Raf-mediated signal transduction pathways. This inhibits cell proliferation in Raf-expressing tumor cells. In addition, this agent may inhibit unidentified RTKs, and thus may further block tumor cell proliferation in susceptible tumor cells. Raf, a serine/threonine protein kinase, plays a key role in the Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway. Deregulation of this pathway often results in tumor cell proliferation and survival.