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CAS No. | 1419949-20-4 | Cat. No. | BCP28685 |
Name | NVP-TNKS656 | ||
Synonyms | NVPTNKS656; NVP TNKS656;TNKS656; TNKS-656; TNKS 656; | ||
SMILES | COC1=CC=C(C=C1)C(=O)C2CCN(CC2)CC(=O)N(CC3CC3)CC4=NC5=C(COCC5)C(=O)N4 | ||
Chemical Name | |||
Formula | C27H34N4O5 | M. Wt | 494.58 |
Purity | 98% | Storage | Store at 4-8°C |
Description | NVP-TNKS656, also known as TNKS656, is a potent and orally active Tankyrase Inhibitor. With an enthalpy-driven thermodynamic signature of binding, highly favorable physicochemical properties, and high lipophilic efficiency, NVP-TNKS656 is well suited for further in vivo validation studies. Bioactivity of TNKS656: TNKS2 IC50 = 6nM, LiPE = 7.0, HEK298 STF IC50 = 3.5nM, Cmax/ Cellular IC50 = 23,000 |
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