Gusacitinib New
Data Sheet
For research use only. Not for human use.
| Size | Price | Stock | Quotation Inquiry |
|---|---|---|---|
| 250.00 mg | Get quote | In-stock | Quotation Inquiry |
| 1.00 g | Get quote | In-stock | Quotation Inquiry |
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| CAS No. | 1425381-60-7 | Cat. No. | BCP31675 |
| Name | Gusacitinib | ||
| Synonyms | ASN-002; ASN 002; ASN002; | ||
| SMILES | C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O | ||
| Chemical Name | |||
| Formula | C24H28N8O2 | M. Wt | 460.54 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Gusacitinib, also known as ASN-002, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and Pfeiffer. | ||
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