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LDN-212854 Chemical Structure

LDN-212854

Data Sheet For research use only. Not for human use.
Cat. No. :BCP14671CAS No. :143259726-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 143259726-6 Cat. No. BCP14671
Name LDN-212854
Synonyms LDN 212854;LDN212854;
SMILES C12=C(C3=C4N=CC(C5=CC=C(N6CCNCC6)C=C5)=CN4N=C3)C=CC=C1N=CC=C2
Chemical Name
Formula C25H22N6 M. Wt 406.48
Purity 98% Storage Store at 4-8°C
Description LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity, and function. LDN-212854 potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. The bone morphogenetic protein (BMP) signaling pathway has essential functions in development, homeostasis, and the normal and pathophysiologic remodeling of tissues. Small molecule inhibitors of the BMP receptor kinase family have been useful for probing physiologic functions of BMP signaling in vitro and in vivo and may have roles in the treatment of BMP-mediated diseases.
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