PD 161570 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 192705-80-9 | Cat. No. | BCP24138 |
| Name | PD 161570 | ||
| Synonyms | PD 161570; PD161570; | ||
| SMILES | CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=C(C=CC=C3Cl)Cl)NC(=O)NC(C)(C)C | ||
| Chemical Name | |||
| Formula | C26H35Cl2N7O | M. Wt | 532.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PD-161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). PD 161570 had about 5- and 100-fold greater selectivity toward the FGF-1 receptor (IC50 = 40 nM) compared with the PDGFbeta receptor (IC50 = 262 nM) or EGF receptor (IC50 = 3.7 microM) tyrosine kinases, respectively. In addition, PD 161570 suppressed constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A121(p)) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A121(p) cells in culture. The results demonstrate a novel synthetic inhibitor with nanomolar potency and specificity towards the FGF-1 receptor tyrosine kinase. | ||
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