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SB 525334 Chemical Structure

SB 525334

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02045CAS No. ：356559-20-1Purity：>97.7%
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  • Chemical Properties&Biological Activity
CAS No. 356559-20-1 Cat. No. BCP02045
Name SB 525334
Synonyms SB-525334;SB525334;
SMILES
Chemical Name
Formula C21H21N5 M. Wt 343.42
Purity >97.7% Storage Store at 4-8°C
Description SB 525334 shows no inhibition in the enzymes ALK2, 3, and 6, with IC50 values > 10 μM. SB 525334 blocks phosphorylation induced by TGF-β1 and nuclear translocation of Smad2/3 in renal proximal tubule cells. SB 525334 also inhibits the increased mRNA expression levels of plasminogen activator inhibitor-1 (PAI-1) and procollagen α1induced by TGF-β1 in A498 renal epithelial carcinoma cells at 1 μM). SB 525334 (1 μM) attenuates the heightened sensitivity to TGF-β1 exhibited by pulmonary artery smooth muscle cells (PASMCs) from patients with familial forms of idiopathic pulmonary arterial hypertension (PAH).
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