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CAS No. | 1445385-02-3 | Cat. No. | BCP30568 |
Name | Lumicitabine | ||
Synonyms | ALS-8176; ALS8176;ALS 8176; JNJ 64041575; JNJ64041575; JNJ-64041575; AL 8176; AL8176; AL-8176; ALS 008176; ALS 008176; ALS008176; | ||
SMILES | CC(C)C(=O)OCC1(C(C(C(O1)N2C=CC(=NC2=O)N)F)OC(=O)C(C)C)CCl | ||
Chemical Name | |||
Formula | C18H25ClFN3O6 | M. Wt | 433.86 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Lumicitabine, also known as ALS-8176, is an orally bioavailable prodrug of the novel RSV replication inhibitor ALS-8112. In nonclinical studies, ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. |
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