Sisunatovir HCl New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1903763-83-6 | Cat. No. | BCP40521 |
| Related Products | 1903763-82-5（Sisunatovir） | ||
| Name | Sisunatovir HCl | ||
| Synonyms | Sisunatovir hydrochloride;RV521 Hydrochloride;RV-521 HCl; | ||
| SMILES | C1CC12C3=C(C=C(C=C3)F)N(C2=O)CC4=NC5=C(N4CCCC(F)(F)F)C=CC(=C5)CN.Cl | ||
| Chemical Name | |||
| Formula | C23H23ClF4N4O | M. Wt | 482.91 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sisunatovir, also known as RV521, is a highly potent fusion inhibitor with efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses. RV521 exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Oral bioavailability in preclinical species ranged from 42 to >100% with evidence of highly efficient penetration into lung tissue. In healthy adult human volunteers experimentally infected with RSV, a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo. | ||
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