PF-06424439 Mesylate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1469284-79-4 | Cat. No. | BCP43812 |
| Name | PF-06424439 Mesylate | ||
| Synonyms | PF 06424439 Mesylate; PF06424439 Mesylate; | ||
| SMILES | CS(=O)(=O)O.C1CCN(C1)C(=O)C2CCCN(C2)C3=NC4=C(C=C3)NC(=N4)C5(CC5)N6C=C(C=N6)Cl | ||
| Chemical Name | |||
| Formula | C23H30ClN7O4S | M. Wt | 536.05 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-06424439 Mesylate is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).PF 06424439 is a potent, selective and orally bioavailable Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1, which exhibits no significant activity at MGAT1-3 or DGAT1. It reduces triglyderide synthesis in human hepatocytes in vitro, and reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. | ||
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