GSK2981278 New
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| CAS No. | 1474110-21-8 | Cat. No. | BCP17156 |
| Name | GSK2981278 | ||
| Synonyms | GSK-2981278;GSK 2981278;ROR gama modulator 1; | ||
| SMILES | O=S(C1=CC=C(OCC2CCOCC2)C(CO)=C1)(N(C3=CC=C(CC)C=C3)CC(C)C)=O | ||
| Chemical Name | |||
| Formula | C25H35NO5S | M. Wt | 461.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). GSK2981278 is a strong RORγ-selective inverse agonist that inhibits activation of the il17 promoter. GSK2981278 robustly inhibits RORγ-mediated cytokine production at both the mRNA and protein level. GSK2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK2981278 will significantly limit Th17-type cytokine expression and should therefore lead to improved clinical outcomes for patients. | ||
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