Bosentan New
Data Sheet
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| CAS No. | 147536-97-8 | Cat. No. | BCP05202 |
| Name | Bosentan | ||
| Synonyms | |||
| SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC | ||
| Chemical Name | |||
| Formula | C27H29N5O6S | M. Wt | 551.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension. | ||
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