MTI-31 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP36715CAS No. ：1567915-38-1Purity：98%

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CAS No.	1567915-38-1	Cat. No.	BCP36715
Name	MTI-31
Synonyms	MTI31;MTI 31;LXI-15029;mTOR inhibitor-31;
SMILES	CC1COCCN1C2=NC3=C(C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)C(=N2)N5C6CCC5COC6
Chemical Name
Formula	C26H30N6O3	M. Wt	474.57
Purity	98%	Storage	Store at 4-8°C
Description	MTI-31 is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G; showed an IC50 value 39 nM in LANCE® assay of mTOR substrate phosphorylation; dose-dependently inhibits of both the mTORC1 substrates P-S6K1(T389), P-S6(S235/6), P-4EBP1(T70) and mTORC2 substrate P-AKT(S473) tumor cell lines harboring mTOR pathway dysregulation with IC50 of <0.12 uM; potently inhibited cell proliferation (IC50 <1 mmol/L) and in vivo tumor growth in multiple NSCLC models of EGFR/T790M, EML4-ALK, c-Met or KRAS (MED <10 mg/kg), also suppressed programmed death ligand 1 (PD-L1) in EGFR- and ALK-driven NSCLC, mediated in part by mTORC2/AKT/GSK3β-dependent proteasomal degradation.