BMS-986115 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP49196CAS No. ：1584647-27-7Purity：98%

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CAS No.	1584647-27-7	Cat. No.	BCP49196
Name	BMS-986115
Synonyms	Notch inhibitor 1; BMS 986115; BMS986115;AL-102;AL 102;AL102;
SMILES	CC1=C2C(=CC=C1)C(=NC(C(=O)N2)NC(=O)C(CCC(F)(F)F)C(CCC(F)(F)F)C(=O)N)C3=CC(=CC=C3)F
Chemical Name
Formula	C26H25F7N4O3	M. Wt	574.49
Purity	98%	Storage	Store at 4-8°C
Description	BMS-986115 is an orally bioavailable, gamma secretase (GS) and pan-Notch inhibitor, with potential antineoplastic activity. Upon administration, GS/pan-Notch inhibitor BMS 986115 binds to GS and blocks the proteolytic cleavage and release of the Notch intracellular domain (NICD), which would normally follow ligand binding to the extracellular domain of the Notch receptor. This prevents both the subsequent translocation of NICD to the nucleus to form a transcription factor complex and the expression of Notch-regulated genes. This results in the induction of apoptosis and the inhibition of growth of tumor cells that overexpress Notch. Overexpression of the Notch signaling pathway plays an important role in tumor cell proliferation and survival.