NVS-ZP7-4 New
Data Sheet
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| CAS No. | 2349367-89-9 | Cat. No. | BCP32718 |
| Name | NVS-ZP7-4 | ||
| Synonyms | NVS-ZP7 4; NVS-ZP74; NVSZP7-4; NVSZP7 4; NVSZP74; | ||
| SMILES | C1CN(CCC12C3=CC=CC=C3NC(=O)N2)CC(CC4=CC=CC=C4)NC5=NC6=C(S5)C=C(C=C6)F | ||
| Chemical Name | |||
| Formula | C28H28FN5OS | M. Wt | 501.62 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7 in cells, suggesting a direct interaction between the compound and ZIP7. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. | ||
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