MLi-2 New
Data Sheet
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| CAS No. | 1627091-47-7 | Cat. No. | BCP35880 |
| Name | MLi-2 | ||
| Synonyms | MLi 2; MLi2; | ||
| SMILES | CC1CN(CC(O1)C)C2=NC=NC(=C2)C3=NNC4=C3C=C(C=C4)OC5(CC5)C | ||
| Chemical Name | |||
| Formula | C21H25N5O2 | M. Wt | 379.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM). MLi-2 has greater than 295-fold selectivity for over 300 kinases in addition to a diverse panel of receptors and ion channels. | ||
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