Ruboxistaurin hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 169939-93-9 | Cat. No. | BCP25875 |
| Related Products | 192050-59-2（Ruboxistaurin mesylate） 169939-94-0（Ruboxistaurin） | ||
| Name | Ruboxistaurin hydrochloride | ||
| Synonyms | Ruboxistaurin HCl ; LY-333531 HCl ;LY 333531 HCl ;LY333531 HCl ;LY 333531 hydrochloride; LY-333531 hydrochloride; LY333531 hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H28N4O3.HCl | M. Wt | 505.01 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Ruboxistaurin hydrochloride is a isozyme-selective inhibitor of protein kinase C (PKC), a competitive reversible inhibitors of PKCβI and PKCβII with IC50 value of 4.7 nM and 5.9 nM respectivily. target: PKC β1/β2 [1] IC50: 4.7 ( PKCβI ), 5.9 nM ( PKCβII ) In vivo: A significant up-regulation of TGF-b1, Smad2 and Smad3 mRNA expression was observed in diabetic rats, which was alleviated by administration of ruboxistaurin. | ||
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