TX-1918 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 503473-32-3 | Cat. No. | BCP16358 |
| Name | TX-1918 | ||
| Synonyms | TX 1918;TX1918; | ||
| SMILES | CC1=CC(=CC(=C1O)C)C=C2C(=O)C=CC2=O | ||
| Chemical Name | |||
| Formula | C14H12O3 | M. Wt | 228.24 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM). It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 µM, respectively).TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with ≥5,000-fold and ≥90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17. | ||
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