PF-543 HCl New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1706522-79-3 | Cat. No. | BCP26198 |
| Name | PF-543 HCl | ||
| Synonyms | PF-543 hydrochloride; PF543 hydrochloride; PF 543 hydrochloride; | ||
| SMILES | OC[C@@H]1N(CC2=CC=C(COC3=CC(CS(=O)(C4=CC=CC=C4)=O)=CC(C)=C3)C=C2)CCC1.[H]Cl | ||
| Chemical Name | |||
| Formula | C27H32ClNO4S | M. Wt | 502.06 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-543 HCl is the hydrochloride salt form of PF-543.PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling. | ||
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