EN6 New
Data Sheet
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| CAS No. | 1808714-73-9 | Cat. No. | BCP34911 |
| Name | EN6 | ||
| Synonyms | EN-6; EN 6; | ||
| SMILES | C=CC(=O)NC1=C(C=CC(=C1)NC(=O)C2=CN(N=C2)C3=CC=CC=C3F)F | ||
| Chemical Name | |||
| Formula | C19H14F2N4O2 | M. Wt | 368.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. | ||
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