Bomedemstat ditosylate New
Data Sheet
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| CAS No. | 1990504-72-7 | Cat. No. | BCP44102 |
| Related Products | 1990504-34-1（Bomedemstat） | ||
| Name | Bomedemstat ditosylate | ||
| Synonyms | IMG-7289 ditosylate; IMG 7289; IMG7289; | ||
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCN(CC1)C(=O)C(CCCNC2CC2C3=CC=C(C=C3)F)NC(=O)C4=CC=C(C=C4)N5C=CN=N5 | ||
| Chemical Name | |||
| Formula | C42H50FN7O8S2 | M. Wt | 864.02 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Bomedemstat is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndrome, and Myelofibrosis. IMG-7289 selectively inhibited proliferation and induced apoptosis of JAK2 V617F cells by concomitantly increasing expression and methylation of p53, and, independently, the pro-apoptotic factor PUMA and by decreasing the levels of its antiapoptotic antagonist BCLXL. | ||
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