JQKD-82 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2410512-38-6 | Cat. No. | BCP44757 |
| Name | JQKD-82 | ||
| Synonyms | JQKD82; JQKD 82; PCK82; PCK-82; PCK 82;JADA82; | ||
| SMILES | CCN(CCN(C)C)C(=O)CNCC1=NC=CC(=C1)C(=O)OC2=C(C=C(C=C2)OC(C)C)OC(C)C | ||
| Chemical Name | |||
| Formula | C27H40N4O5 | M. Wt | 500.64 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50 = 0.42 uM). JQKD82 increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a useful tool compound to block KDM5A function as a potential therapeutic strategy for MM. QKD82 is a more stable ester of KDM5-C49 that is able to deliver the active molecule KDM5-C49 to cells more efficiently | ||
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