cis-Pralsetinib New
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| CAS No. | 2097132-93-7 | Cat. No. | BCP31224 |
| Name | cis-Pralsetinib | ||
| Synonyms | cis-Blu667;cis-Blu 667;cis-Blu-667;BLU-667 trans form; | ||
| SMILES | CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)NC(C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC | ||
| Chemical Name | |||
| Formula | C27H32FN9O2 | M. Wt | 533.6 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | cis-Pralsetinib is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types. | ||
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