NCT-505 New
Data Sheet
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| CAS No. | 2231079-74-4 | Cat. No. | BCP44645 |
| Name | NCT-505 | ||
| Synonyms | NCT 505; NCT505; | ||
| SMILES | CS(=O)(=O)N1CCN(CC1)C(=O)C2=CN=C3C=CC(=CC3=C2N4CCC(CC4)(C#N)C5=CC=CC=C5)F | ||
| Chemical Name | |||
| Formula | C27H28FN5O3S | M. Wt | 521.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NCT-505 is an Orally Bioavailable aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitor with Potent Cellular Activity (IC50 = 7 nM). NCT-505 demonstrated target engagement in a cellular thermal shift assay (CETSA), inhibited the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiated the cytotoxicity of paclitaxel in SKOV-3-TR, a paclitaxel resistant ovarian cancer cell line. NCT-505 also exhibit high specificity over other ALDH isozymes and unrelated dehydrogenases. | ||
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