Mavorixafor trihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2309699-17-8 | Cat. No. | BCP32916 |
| Related Products | 558447-26-0（Mavorixafor） 880549-30-4（Mavorixafor hydrochloride） | ||
| Name | Mavorixafor trihydrochloride | ||
| Synonyms | Mavorixafor 3HCl;AMD-070 trihydrochloride;AMD070 trihydrochloride; | ||
| SMILES | C1CC(C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3.Cl.Cl.Cl | ||
| Chemical Name | |||
| Formula | C21H30Cl3N5 | M. Wt | 458.86 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Mavorixafor is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas. | ||
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