NBI-74330 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 855527-92-3 | Cat. No. | BCP34091 |
| Name | NBI-74330 | ||
| Synonyms | NBI 74330; NBI74330; | ||
| SMILES | CCOC1=CC=C(C=C1)N2C(=O)C3=C(N=CC=C3)N=C2C(C)N(CC4=CN=CC=C4)C(=O)CC5=CC(=C(C=C5)F)C(F)(F)F | ||
| Chemical Name | |||
| Formula | C32H27F4N5O3 | M. Wt | 605.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NBI-74330 is an antagonist of CXC chemokine receptor 3 (CXCR3) with IC50 values of 7nM to18nM. NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor-deficient mice. Chemokine receptor CXCR3 promotes growth of glioma. CXCR3 antagonism exerts a direct anti-glioma effect and this receptor may be a potential therapeutic target for treating human GBM. | ||
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