SIAIS178 New
Data Sheet
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| CAS No. | 2376047-73-1 | Cat. No. | BCP34391 |
| Name | SIAIS178 | ||
| Synonyms | SIAIS-178; | ||
| SMILES | CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)C(=O)CCCCCCC(=O)NC(C(=O)N5CC(CC5C(=O)NCC6=CC=C(C=C6)C7=C(N=CS7)C)O)C(C)(C)C | ||
| Chemical Name | |||
| Formula | C50H62ClN11O6S2 | M. Wt | 1012.68 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SIAIS178 ist ein potenter und selektiver BCR-ABL-Abbauer auf Basis der PROTAC-Technologie mit einem IC50 von 24 nM. SIAIS178 verursacht einen effektiven Abbau des BCR-ABL-Proteins durch die Rekrutierung von Von Hippel-Lindau (VHL) E3-Ubiquitin-Ligase. | ||
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