ARV393 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2851885-95-3 | Cat. No. | BCP49670 |
| Name | ARV393 | ||
| Synonyms | ARV-393;ARV 393; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C46H53ClFN9O7 | M. Wt | 898.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon, respectively. ARV-393 has DC50 and GI50 values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models. ARV-393 is being studied to inhibit non-Hodgkin lymphoma. | ||
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