WDR5-IN-1 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2408842-51-1 | Cat. No. | BCP49073 |
| Name | WDR5-IN-1 | ||
| Synonyms | |||
| SMILES | CC1=C(C=CC(=C1)F)C2=C3CCN(C(=O)C3=CC(=C2)CN4C=CN(C4=N)C)CC5=CC(=CC(=C5)OC)OC | ||
| Chemical Name | |||
| Formula | C30H31FN4O3 | M. Wt | 514.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a Kd of <0.02 nM. WDR5-IN-1 inhibits MLL1 histone methyltransferase (HMT) activity with an IC50 of 2.2 nM. WDR5-IN-1 diminishes MYC recruitment at WDR5-displaced genes and exhibits potent anti-proliferative effects in CHP-134 (neuroblastoma) and Ramos (Burkitt’s lymphoma) lines. | ||
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