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TP-064 Chemical Structure

TP-064

Data Sheet For research use only. Not for human use.
Cat. No. :BCP43164CAS No. :2080306-20-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2080306-20-1 Cat. No. BCP43164
Name TP-064
Synonyms TP 064; TP064;
SMILES CNCCN1CCC(CC1)C2=NC=CC(=C2)CN(C)C(=O)C3=CC(=CC=C3)OC4=CC=CC=C4
Chemical Name
Formula C28H34N4O2 M. Wt 458.6
Purity 98% Storage Store at 4-8°C
Description TP-064 is a potent and selective PRMT4 inhibitor. The in vitro activity of TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cellular assays, TP-064 inhibits the methylation of MED12 with IC50 = 43 nM.
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