Ro 0281675

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16457CAS No. ：300353-13-3Purity：98%

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CAS No.	300353-13-3	Cat. No.	BCP16457
Name	Ro 0281675
Synonyms	Ro-0281675;Ro0281675; Ro 28-1675;
SMILES
Chemical Name
Formula	C18H22N2O3S2	M. Wt	378.51
Purity	98%	Storage	Store at 4-8°C
Description	IC50 value: 0.24± 0.0019 uM (SC1.5) Target: Glucokinase activator The R stereoisomer Ro 28-1675 activated GK with a SC1.5 of 0.24 uM, while the S isomer did not activated GK up to 10 uM. Oral administration of Ro 28-1675 (50 mg/Kg) to male C57B1/6J mice caused a statistically significant reduction in fasting glucose levels and improvement in glucose tolerance relative to the vehicle treated animals . Comparison of rat PK parameters indicated that Ro 28-1675 displayed lower clearance and higher oral bioavailability compared to 9a. Following a single oral dose, Ro 28-1675 reduced fasting and postprandial glucose levels following an OGTT, was well tolerated, and displayed no adverse effects related to drug administration other than hypoglycemia at the maximum dose (400 mg).