ZK53 New
Data Sheet
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| CAS No. | 3031789-26-8 | Cat. No. | BCP49658 |
| Name | ZK53 | ||
| Synonyms | ZK 53;ZK-53;1-Piperazinecarboxamide, N-[(4-bromophenyl)methyl]-4-[(3,5-difluorophenyl)methyl]-; | ||
| SMILES | C1CN(CCN1CC2=CC(=CC(=C2)F)F)C(=O)NCC3=CC=C(C=C3)Br | ||
| Chemical Name | |||
| Formula | C19H20BrF2N3O | M. Wt | 424.28 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37μM for α-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model. | ||
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