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Cinacalcet hydrochloride Chemical Structure

Cinacalcet hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02533CAS No. :364782-34-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 364782-34-3 Cat. No. BCP02533
Name Cinacalcet hydrochloride
Synonyms Cinacalcet HCl;Mimpara;Sensipar;AMG-073;AMG 073;AMG073;
SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl
Chemical Name
Formula C22H22F3N.HCl M. Wt 393.88
Purity 98% Storage Store at 4-8°C
Description Cinacalcet Hydrochloride is the orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth.
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