HI-TOPK-032 New
Data Sheet
For research use only. Not for human use.
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Publications Citing of Biochempartner's HI-TOPK-032
| CAS No. | 487020-03-1 | Cat. No. | BCP35692 |
| Name | HI-TOPK-032 | ||
| Synonyms | HI-TOPK032; HI-TOPK 032; | ||
| SMILES | C1=CC=C2C(=C1)N=C3C(=C4C=C(C=CN4C3=N2)NC(=O)C5=CC=CS5)C#N | ||
| Chemical Name | |||
| Formula | C20H11N5OS | M. Wt | 369.4 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | HI-TOPK-032 is a potent and selective TOPK inhibitor. In vitro, HI-TOPK-032 strongly suppressed TOPK kinase activity but had little effect on extracellular signal–regulated kinase 1 (ERK1), c-jun—NH2—kinase 1, or p38 kinase activities. HI-TOPK-032 also inhibited anchorage-dependent and -independent colon cancer cell growth by reducing ERK-RSK phosphorylation as well as increasing colon cancer cell apoptosis through regulation of the abundance of p53, cleaved caspase-7, and cleaved PARP. In vivo, administration of HI-TOPK-032 suppressed tumor growth in a colon cancer xenograft model. HI-TOPK-032 may be further developed as a potential therapeutic against colorectal cancer. The serine-threonine mitogen-activated protein kinase kinase family member T-LAK cell–originated protein kinase (TOPK/PBK) is heavily involved in tumor development, cancer growth, apoptosis, and inflammation ( Cancer Res; 72(12); 3060–8.). | ||
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