Aloisine A New
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| CAS No. | 496864-16-5 | Cat. No. | BCP26893 |
| Name | Aloisine A | ||
| Synonyms | RP107;RP-107;RP 107; | ||
| SMILES | CCCCC1=C(NC2=NC=CN=C12)C3=CC=C(C=C3)O | ||
| Chemical Name | |||
| Formula | C16H17N3O | M. Wt | 267.33 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Aloisine A (RP107) is a a potent cyclin-dependent kinase (CDK) inhibitor with IC50s of 0.15 μM, 0.12 μM, 0.4 μM, 0.16 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p35, respectively. Aloisine A ininhibits GSK-3α (IC50=0.5 μM) and GSK-3β (IC50=1.5 μM). Aloisine A stimulates wild-type CFTR and mutated CFTR, with submicromolar affinity by a cAMP-independent mechanism. Aloisine A has the potential for CFTR-related diseases, including cystic fibrosis research. | ||
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