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Glycochenodeoxycholic acid Chemical Structure

Glycochenodeoxycholic acid

Data Sheet For research use only. Not for human use.
Cat. No. :BCP49686CAS No. :640-79-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 640-79-9 Cat. No. BCP49686
Name Glycochenodeoxycholic acid
Synonyms GCDC;Glycochenodeoxycholate;Chenodeoxycholylglycine;Glycine chenodeoxycholate;
SMILES CC(CCC(=O)NCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
Chemical Name
Formula C26H43NO5 M. Wt 449.62
Purity 98% Storage Store at 4-8°C
Description Glycochenodeoxycholic acid is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC).
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