Daporinad New
Data Sheet
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| CAS No. | 658084-64-1 | Cat. No. | BCP01909 |
| Name | Daporinad | ||
| Synonyms | APO-866;APO 866;APO866;FK-866;FK 866;FK866;1198425-96-5; | ||
| SMILES | O=C(NCCCCC1CCN(C(C2=CC=CC=C2)=O)CC1)/C=C/C3=CC=CN=C3 | ||
| Chemical Name | |||
| Formula | C24H29N3O2 | M. Wt | 391.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Daporinad, also known as APO-866 and FK866, is a small molecule with potential antineoplastic and antiangiogenic activities. NMPRTase inhibitor APO866 binds to and inhibits nicotinamide phosphoribosyltransferase (NMPRTase), inhibiting the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from niacinamide (vitamin B3), which may deplete energy reserves in metabolically active tumor cells and induce tumor cell apoptosis. In addition, this agent may inhibit tumor cell prioduction of vascular endothelial growth factor (VEGF), resulting in the inhibition of tumor angiogenesis. | ||
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