Vanoxerine New
Data Sheet
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| CAS No. | 67469-69-6 | Cat. No. | BCP21322 |
| Name | Vanoxerine | ||
| Synonyms | GBR-12909; GBR12909; GBR 12909; I-893; I 893; I893; | ||
| SMILES | C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | ||
| Chemical Name | |||
| Formula | C28H32F2N2O | M. Wt | 450.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM; Vanoxerine also is a potent hK(v)11.1 blocker, and at submicromolar concentrations, it blocks Ca and Na currents in a strongly frequency-dependent manner possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but with cardiac ion channel effects. | ||
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