Phlorizin dihydrate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 7061-54-3 | Cat. No. | BCP49110 |
| Name | Phlorizin dihydrate | ||
| Synonyms | Phlorizin 2H2O; | ||
| SMILES | C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O.O.O | ||
| Chemical Name | |||
| Formula | C21H24O10.2H2O | M. Wt | 472.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Phlorizin, also referred to as phloridzin, is a glucoside of phloretin, a dihydrochalcone, a family of bicyclic flavonoids, which in turn is a subgroup in the diverse phenylpropanoid synthesis pathway in plants. Phlorizin is a competitive inhibitor of SGLT1 and SGLT2 because it competes with D-glucose for binding to the carrier; this reduces renal glucose transport, lowering the amount of glucose in the blood. Phlorizin was studied as a potential pharmaceutical treatment for type 2 diabetes, but has since been superseded by more selective and more promising synthetic analogs, such as canagliflozin and dapagliflozin. | ||
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