8,9-Eet New
Data Sheet
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| CAS No. | 81246-85-7 | Cat. No. | BCP47805 |
| Name | 8,9-Eet | ||
| Synonyms | (+/-)8,9-EET;8,9-Epoxyeicosatrienoic acid; | ||
| SMILES | CCCCCC=CCC=CCC1C(O1)CC=CCCCC(=O)O | ||
| Chemical Name | |||
| Formula | C20H32O3 | M. Wt | 320.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | (±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid. (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARα in HEK293 cells when used at a concentration of 1 µM but inhibits NF-κB activity induced by IL-1β in a PPARα-dependent and -independent fashion. It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM. (8S,9R)-EET (1 µg/kg), but not (8R,9S)-EET, reduces the glomerular filtration rate (GFR) through COX-dependent pre-glomerular vasoconstriction in rats. | ||
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